Project 2. Gene regulatory networks of neural stem cell neurogenesis

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Neural stem cells are primary progenitors isolated from the mammalian central nervous system (CNS) at the embryonic and adult stage. They are valuable tools in novel strategies of gene therapy for human diseases, including nervous system repair and regeneration. We use differentiating neural stem cells for modelling neurodevelopmental diseases and address basic mechanisms of neuronal and glial differentiation. By using genome-wide and candidate gene approaches, combined with molecular and cellular biology techniques and gene therapy strategies, we study the genetic regulatory networks of neural stem cells. We have a clear focus on DNA methylation and MeCP2 homeostasis regulatory network. Our research will help to understand how deficiencies at the molecular and cellular levels would lead to impaired brain function and will ultimately be useful for developing effective therapeutic strategies that impact brain function.