Publications & Journal Articles
Arezoumand K, Roberts C-H, and Rastegar M. Metformin induces MeCP2 in the hippocampus of male mice with sex-specific and brain region-dependent molecular impact. Biomolecules 2024. 14 (4), 505(1-17). Doi: https://doi.org/10.3390/biom14040505
Liu L, Nguyen H, Das U, Ogunsola S, Yu JK, Pejhan S, Rastegar M, Jiuyong Xie. Epigenetic control of adaptive or homeostatic splicing during interval-training activities. Nucleic Acid Research (NAR) 2024. gkae311 (1-14). Doi: https://doi.org/10.1093/nar/gkae311
Roberts C-H, Arezoumand K, Shahib AK, Davie JR, and Rastegar M. Epigenetics in rare neurological diseases. Frontiers in Cell & Developmental Biology 2024. In press
Lockman S, Genung M, Sheikholeslami K, Ali Sher A, Kroft D, Buist M, Olson CO, Toor B, and Rastegar M. Transcriptional inhibition of the Mecp2 promoter by MeCP2E1 and MeCP2E2 isoforms suggests negative auto-regulatory feedback that can be moderated by metformin. Journal of Molecular Neuroscience 2024. 74-14 (1-11). Doi: https://doi.org/10.1007/s12031-023-02177-0
Rastegar M. Editorial: New Insights into the Molecular Mechanisms of Autistic Spectrum Disorders. Frontiers in Molecular Neuroscience 2024. 17 (1-2). Doi: https://doi.org/10.3389/fnmol.2024.1363999
Nejati-Koshki K*, Roberts C*-H (*equal contribution), Babaei G, and Rastegar M. The Epigenetic Reader Methyl-CpG-Binding Protein 2 (MeCP2) Is an Emerging Oncogene in Cancer Biology. Cancers 2023. 15(10), 2683 (1-22); Doi: https://doi.org/10.3390/cancers15102683
Rastegar M, Davie JR. Editorial: MeCP2 is the Protector of Epigenome Integrity, Membrane-less Nuclear Architecture, and Stability of Chromatin Assembly. Epigenomics 2023. 15(20):1027-1031. Doi: https://doi.org/10.2217/epi-2023-0310
My Vuu Y, Shahib AK, and Rastegar M. The potential therapeutic application of simvastatin for brain complications and mechanisms of action. Pharmaceuticals 2023. 16, 914 (1-26). Doi: https://doi.org/10.3390/ph16070914
Sattarifard H, Safaei A, Khazeeva E, Rastegar M, and Davie JR. Mitogen- and stress-activated protein kinase (MSK1/2) regulated gene expression in normal and disease states. Biochemistry and Cell Biology 2023. Doi: 10.1139/bcb-2022-0371.
Vuu YM, Roberts C-T, Rastegar M. MeCP2 is an epigenetic factor that links DNA methylation with brain metabolism. International Journal of Molecular Sciences (IJMS) 2023. 24, 4, 4218 (1- 32). Doi: Doi.org/10.3390/ijms24044218
Cho WC, Pérez-Tur J, Giugno R, Pirooznia M, Boris-Lawrie K, Greenbaum D, Rastegar M, Henrique R, Xu P, Teixeira da Rocha JB, Rogina B. Editorial: 10 Years of Frontiers in Genetics: past discoveries, current challenges and future perspectives. Frontiers in Genetics 2023. Doi:10.3389/fgene.2023.1192071 (1-3)
Imani M, Mohajeri N, Rastegar M, and Nosratollah N. Synthesis and Characterization of N-rich Fluorescent Bio-dots as a Reporter in the Design of Dual-labeled FRET Probe for TaqMan PCR: a Feasibility Study. Biotechnology and Applied Biochemistry 2023. 70(2):645-658, Doi: 10.1002/bab.2387
Ruden DM, and Rastegar M. Editorial: Insights in Epigenomics and Epigenetics: 2022. Frontiers in Genetics 2023, 14 (1-2). Doi: https://doi.org/10.3389/fgene.2023.1205975
Buist M, El-Tobgy N, Shevkoplyas D, Genung M, Sher AA, Pejhan S, Rastegar M. Differential sensitivity of the protein translation initiation machinery and mTOR signaling to MECP2 gain- and loss-of-function involves MeCP2 isoform-specific homeostasis in the brain. Cells 2022. 11(9):1442 (1-32). Doi: https://doi.org/10.3390/cells11091442
Shevkoplyas D, Vuu YM, Davie JR, Rastegar M. The Chromatin structure at the MECP2 gene and in Silico prediction of potential coding and non-coding MECP2 splice variants. International Journal of Molecular Sciences (IJMS) 2022. 23, 24 (1-26). Doi.org/10.3390/ijms232415643
Nejati K, Rastegar M, Fathi F, Dadashpour M, Arabzadeh AA. Nanoparticle-based drug delivery systems to overcome gastric cancer drug resistance. Journal of Drug Delivery Science and Technology 2022, 70, 103231
Bin Akhtar G*, Buist M* (*equal contribution), Rastegar M. MeCP2 and transcriptional control of eukaryotic genes. European Journal of Cell Biology 2022 . 101, 3, 151237 (1-19). Doi: 10.1016/j.ejcb.2022.151237
Imani M, Mohajeri N, Rastegar M, Zarghami N. Synthesis and characterization of N‐rich fluorescent bio‐dots as a reporter in the design of dual‐labeled FRET probe for TaqMan PCR: A feasibility study. Biotechnology and Applied Biochemistry 2022. Doi.org/10.1002/bab.2387
Buist M, Fuss D, Rastegar M. Transcriptional regulation of MECP2E1-E2 Isoforms and BDNF by metformin and simvastatin through analyzing nascent RNA synthesis in a human brain cell line. Biomolecules 2021.11(8):1253 (1-19). Doi: 10.3390/biom11081253.
Rastegar M, Yasui DH. Editorial: Epigenetic mechanisms and their involvement in rare diseases. Frontiers in Genetics 2021. 12:755076. Doi: 10.3389/fgene.2021.755076
Imani N, Mohajeri N, Rastegar M, & Zarghami N. Recent advances in FRET-Based biosensors for biomedical applications. Analytical biochemistry 2021. 630, 114323 (1-14). Doi: 10.1016/j.ab.2021.114323
Pejhan S, & Rastegar M. Role of DNA-Methyl CpG-Binding protein MeCP2 in Rett Syndrome pathobiology and mechanism of disease. Biomolecules 2021. 11 (1) 75 (1-27). Doi: https://doi.org/10.3390/biom11010075
Amiri S, Davie JR, & Rastegar M. Chronic ethanol exposure alters DNA methylation in neural stem cells; Role of mouse strain and sex. Molecular Neurobiology 2020. 57, 2 (650-667), Doi.org/10.1007/s12035-019-01728-0
Pejhan S, Del Bigio MR, & Rastegar M. The MeCP2E1/E2-BDNF-miR132 homeostasis regulatory network is region-dependent in the human brain and is impaired in Rett Syndrome patients. Frontiers in Cell and Developmental Biology 2020. 7, 863 (1-14) Doi: 10.3389/fcell.2020.00763
Vriend J, & Rastegar M. Ubiquitin ligases and medulloblastoma: genetic markers of the four consensus subgroups identified through transcriptome datasets. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2020. 1866(10): 165839. Doi: 10.1016/j.bbadis.2020.165839
Pejhan S, Mok Siu V, Ang LC, Del Bigio MR, & Rastegar M. Differential brain region-specific expression of MeCP2 and BDNF in Rett Syndrome patients: A distinct grey-white matter variation. Neuropathology and Applied Neurobiology 2020. 46, 7 (735-750) Doi: 10.1111/nan.12619
Liyanage VRB, Olson CO, Zachariah RM, Davie JR, & Rastegar M. DNA methylation contributes to the differential expression levels of Mecp2 in male mice neurons and astrocytes. International Journal of Molecular Sciences 2019. 20(8), 1845: 1-15, Doi:10.3390/ijms20081845
Sheikholeslami K*, Ali Sher A*, Lockman S* (*equal contribution), Kroft D, Ghanjibakhsh M, Nejati-Koshki K, Shojaei S, Ghavami S, & Rastegar M. Simvastatin induces apoptosis in medulloblastoma brain tumor cells via mevalonate cascade prenylation substrates. Cancers 2019. 11(7), 994: 1-19, Doi: 10.3390/CANCERS11070994
Xu W, Liyanage VRB, MacAulay A, Levy RD, Curtis K, Olson CO, Zachariah RM, Amiri S, Buist M, Hicks GG, Davie JR, & Rastegar M. Genome-wide transcriptome landscape of embryonic brain-derived neural stem cells exposed to alcohol with strain-specific cross-examination in BL6 and CD1 mice. Scientific Reports 2019. 9:206: 1-17, Doi:10.1038/s41598-018-36059-y
Majidinia M, Reiter RJ, Shakouri SK, Mohebbi I, Rastegar M, Kaviani M, Darband SG, Jahanban-Esfahlan R, Nabavi SM, & Yousefi B. The multiple functions of melatonin in regenerative medicine. Ageing Research Reviews 2018. 45:33-52. Doi: 10.1016/j.arr.2018.04.003
Olson CO, Pejhan S, Kroft D, Sheikholeslami K, Fuss D, Buist M, Ali Sher A, Del Bigio MR, Sztainberg E, Siu VM, Ang LC, Sabourin-Felix M, Moss T, & Rastegar M. MECP2 mutation interrupts nucleolin-mTOR-P70S6K signaling in Rett Syndrome patients. Frontiers in Genetics 2018. 9, 635:1-17, Doi: 10.3389/fgene.2018.00635
Rastegar M. NeuroEpigenetics and neurodevelopmental disorders: From molecular mechanisms to cell fate commitments of the brain cells and human disease. Current Topics in Medicinal Chemistry 2017. 17,1. Doi: 10.2174/1568026616999160812144822
Amiri S, Haj-Mirzaiain A, Momeny M, Amini-Khoei H, Rahimi-Balaei M, Poursaman S, Rastegar M, Nikoui V, Mokhtari T, Ghazi-Khansari M, & Hosseini MJ. Streptozotocin induced oxidative stress, innate immune system responses and behavioral abnormalities in male mice. Neuroscience 2017. 340:373-383. Doi: 10.1016/j.neuroscience.2016.11.003
Amiri S, Haj-Mirzaian A, Amini-Khoei H, Razmi A, Shirzadian A, Rahimi-Balaei M, Olson CO, Mohsenzadeh A, Rastegar M, Zarrindast MR, & Ghazi-Khansari M. Protective effects of gabapentin against the seizure susceptibility and comorbid behavioral abnormalities in the early socially isolated mice. European Journal of Pharmacology 2017. 21; 797:106-114. Doi: 10.1016/j.ejphar.2017.01.024
Amini-Khoei H, Mohammadi-Asl A, Amiri S, Hosseini MJ, Momeny M, Hassanipour M, Rastegar M, Haj-Mirzaian A, Mirzaian AH, Sanjari moghaddam H, Mehr SE, & Dehpour AR. Oxytocin mitigated the depressive-like behaviors of maternal separation stress through modulating mitochondrial function and neuroinflammation. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2017. S0278-5846 (16)30244-5. Doi: 10.1016/j.pnpbp.2017.02.022
Liyanage VRB, Curtis K, Zachariah RM, Crudely A, & Rastegar M. Overview of the genetic basis and epigenetic mechanisms that contribute to FASD pathobiology. Current Topics in Medicinal Chemistry 2017. 17(7), 808-828, Doi: 10.2174/1568026616666160414124816
Amini-Khoei H, Amiri S, Mohammadi-Asl A, Alijanpour S, Poursaman S, Haj-Mirzaian A, Rastegar M, Mesdaghinia A, Banafshe HR, Sadeghi E, Samiei E, Mehr SE, & Dehpour AR. Experiencing neonatal maternal separation increased pain sensitivity in adult male mice: Involvement of oxytocinergic system. Neuropeptides 2017. 61:77-85. Doi: 10.1016/j.npep.2016.11.005
Pandian N, Iqbal MA, Yeung A, Thliveris JA, Rastegar M, Ghavami S, & Eftekharpour E. Perturbation of Redox Balance after Thioredoxin Reductase Deficiency Interrupts Autophagy-Lysosomal Degradation Pathway and Enhances Apoptotic Cell Death in Nutritionally Stressed SH-SY5Y Cells. Free Radical Biology & Medicine 2016. 16: 30440-3. Doi: 10.1016/j.freeradbiomed.2016.09.026
Amiri S, Haj-Mirzaian A, Amini-khoei H, Shirzadian A, Rahimi-Balaei M, Razmi A, Bergen H, Rastegar M, Kordjazy N, Haj-Mirzaian A, Ejtemai-Mehr S, & Dehpour R. Lithium attenuates the proconvulsant effect of adolescent social isolation stress via involvement of the nitrergic system. Epilepsy & Behavior 2016. Doi: http://dx.doi.org/10.1016/j.yebeh.2016.04.035
Amiri S*, Alijanpour S* (*equal contribution), Tirgar F, Haj-Mirzaian A, Amini-Khoei H, Rahimi-Balaei M, Rastegar M, Ghaderi M, Ghazi-Khansari M, & Zarrindast MR. NMDA receptors are involved in the antidepressant-like effects of capsaicin following amphetamine withdrawal in male mice. Neuroscience 2016. Doi: 10.1016/j.neuroscience.2016.05.003
Amiri S, Amini-Khoei H, Mohammadi-Asl A, Alijanpour S, Haj-Mirzaian A, Rahimi-Balaei M, Razmi A, Olson CO, Rastegar M, Mehdizadeh M, & Zarrindast MR. Involvement of D1 and D2 dopamine receptors in the antidepressant-like effects of selegiline in maternal separation model of mouse. Physiology and Behavior 2016. Doi: 10.1016/j.physbeh.2016.04.052
Haj-Mirzaian A, Amiri S, Amini-Khoei H, Rahimi-Balaei M, Kordjazy N, Olson CO, Rastegar M, Naserzadeh P, Marzban H, Dehpour AR, Hosseini MJ, & Ejtemaei Mehr SH. Attenuation of Oxidative and Nitrosative Stress in Cortical Area Contribute to Antidepressant-like Effects of Tropisetron in Male Mice Following Social Isolation Stress. Brain Research Bulletin 2016. Doi: 10.1016/j.brainresbull.2016.04.018
Liyanage VRB, Zachariah RM, Davie JR, & Rastegar M. Ethanol Deregulates Mecp2/MeCP2 in Differentiating Neural Stem Cells via Interplay between 5-Methylcytosine and 5-Hydroxymethylcytosine at the Mecp2 Regulatory Elements. Experimental Neurology 2015, 265: 102-117. Doi: 10.1016/j.expneurol.2015.01.006
Marzban H, Del Bigio MR, Alizadeh J, Ghavami S, Zachariah RM, & Rastegar M. Cellular Commitment in the Developing Cerebellum. Frontiers in Cellular Neuroscience 2015, 8 (450): 1-26. Doi: 10.3389/fncel.2014.00450
Olson CO*, Zachariah RM*, Ezeonwuka CD* (*equal contribution), Liyanage VRB, & Rastegar M. Brain Region-Specific Expression of MeCP2 Isoforms Correlates with DNA Methylation within Mecp2 Regulatory Elements. PLOS ONE 2014, 9(3): e90645. Doi: 10.1371/journal.pone.0090645
Liyanage VRB, & Rastegar M. Rett Syndrome and MeCP2. NeuroMolecular Medicine 2014. Doi: 10.1007/s12017-014-8295-9
Yasui DH, Gonzales ML, Aflatooni JO, Crary FK, Hu DJ, Gavino BJ, Golub MS, Vincent JB, Schanen NC, Olson CO, Rastegar M, & Lasalle JM. Mice with an Isoform-ablating Mecp2-exon 1 Mutation Recapitulate the Neurologic Deficits of Rett Syndrome. Human Molecular Genetics 2014. 1;23(9):2447-58. Doi: 10.1093/hmg/ddt640
Liyanage VRB, Jarmasz J, Murugeshan N, Del Bigio MR, Rastegar M, & Davie JR. DNA Modifications: Function and Applications in Normal and Disease States. Biology 2014. 22;3(4):670-723. Doi: 10.3390/biology3040670
Ezeonwuka CD, & Rastegar M. MeCP2-Related Diseases and Animal Models. Diseases 2014. 2 (1): 45-70
Liyanage VRB, Zachariah RM, & Rastegar M. Decitabine alters the Expression of Mecp2 Isoforms via Dynamic DNA Methylation at the Mecp2 Regulatory Elements in Neural Stem Cells. Molecular Autism 2013. 4:46. Doi: 10.1186/2040-2392-4-46
Barber BA*, Liyanage VRB* (*equal contribution), Zachariah RM, Olson C, Bailey M, & Rastegar M. Dynamic Expression of MEIS1 Homeoprotein in E14.5 Forebrain and Differentiated Forebrain-Derived Neural Stem Cells. Annals of Anatomy 2013. Doi: 10.1016/j.aanat.2013.04.00
Olynik B, & Rastegar M. The Genetic and Epigenetic Journey of Embryonic Stem Cells into Mature Neural Cells. Frontiers in Genetics 2012. 2012;3:81. 1-16.
Sandhu S, Wu X, Nabi Z, Rastegar M, Kung S, Mai S, & Ding H. Loss of HLTF Function Promotes Intestinal Carcinogenesis. Molecular Cancer 2012. 27; 11(1):18, 1-16.
Zachariah RM, & Rastegar M. Linking Epigenetics to Human Disease and Rett Syndrome, the Emerging Novel and Challenging Concepts in MeCP2 Research. Neural Plasticity 2012. 2012: 1-10.
Zachariah RM*, Olson C* (*equal contribution), Ezeowuka Ch, & Rastegar M. Novel MeCP2 Isoform-Specific Antibody Reveals the Endogenous MeCP2E1 Expression in Murine Brain, Primary Neurons and Astrocytes. PLOS ONE 2012. e49763. Doi: 10.1371; 7 (11): 1-10
Barber BA, & Rastegar M. Epigenetic Control of Hox Genes during Neurogenesis, Development and Disease. Annals of Anatomy 2010. 192(5): 261-74 [Artwork selected for cover]
Delcuve GP, Rastegar M, & Davie JR. Epigenetic Control. Journal of Cellular Physiology 2009, 219 (2): 243-50 [Artwork selected for cover]
Rastegar M, Hotta A, Pasceri P, Elliot S, Makarem M, Cheung A, Adachi M, Jones, FS, Clarke I, Dirks P, & Ellis J. Rett Syndrome Neural Stem Cell Gene Transfer with MECP2 Isoform-Specific Vectors. PLOS ONE 2009. 4(8): e6810. Doi: 10.1371, 1-15
Ellis J, Hotta A, & Rastegar M. Retrovirus Silencing by an Epigenetic TRIM. Cell 2007. 131(1): 13-14
Nolte C*, Rastegar M* (*equal contribution), Amores A, Bouchard M, Grote D, Maas R, Nagy Kovacs E, Postlethwait J, Rambaldi I, Rowan Sh, Zhang F, & Featherstone M. Stereospecificity and PAX6 function direct Hoxd4 neural enhancer activity along the antero-posterior axis. Developmental Biology 2006. 15-299(2): 582-93
Kobrossy L, Rastegar M, & Featherstone M. Interplay between chromatin and trans-acting factors regulating the Hoxd4 promoter during neural differentiation. The Journal of Biological Chemistry 2006. 281:25926-39
Huang H, Rastegar M, Bodner C, Goh SL, Rambaldi I, & Featherstone M. Meis C-termini harbor transcriptional activation domains that respond to cell signaling. The Journal of Biological Chemistry 2005. 280:10119-27
Rastegar M, Kobrossy L, Nagy Kovàcs E, Rambaldi I, & Featherstone M. Sequential histone modifications at Hoxd4 regulatory regions distinguish anterior from posterior embryonic compartments. Molecular and Cellular Biology 2004. 24: 8090-8103
Gordon J, Wu CH, Rastegar M, & Safa AR. 2-microglobulin induces caspase-dependent apoptosis in CCRF-HBS-2 human leukemia cell line independently of caspase-3, -8, and -9 pathways but through increased reactive oxygen species. International Journal of Cancer 2003. 103: 316-327
Wu CH, Gordon J, Rastegar M, Ogretmen B, & Safa AR. Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line is down-regulated in its doxorubicin-resistant variant. Oncogene 2002. 21: 5160-5174
Wu CH, Rastegar M, Gordon J, and Safa AR. 2-microglobulin induces apoptosis in HL-60 human leukemia cells and its multidrug resistantvariants overexpressing MRP1 but lacking Bax or overexpressing P- glycoprotein. Oncogene 2001. 25: 7006-7020
Rastegar M, Rousseau GG, & Lemaigre FP. CCAAT/Enhancer Binding Protein alpha (C/EBPa) is a mediator of growth hormone action in the liver and controls the expression of Hepatocyte Nuclear Factor-6 (HNF-6). Endocrinology 2000. 141: 1686-92
Rastegar M, Lemaigre FP, & Rousseau GG. HNF-6: Pièce maîtresse d’un réseau de facteurs de transcription hépatiques contrôlé par l’hormone de croissance. Médicine /Sciences 2000.16: 1106-1108
Lahuna O*, Rastegar M* (*equal contribution), Maiter D, Thissen JP, Lemaigre FP, & Rousseau GG. Involvement of STAT5 and HNF-4 in the transcriptional control of the Hnf6 gene by growth Hormone. Molecular Endocrinology 2000. 14: 285-94
Rastegar M, Lemaigre FP, & Rousseau GG. Control of gene expression by growth hormone in liver: Key role of a network of transcription factors. Molecular and Cellular Endocrinology 2000. 164: 1-4
Rastegar M, Szpirer C, Rousseau GG, & Lemaigre FP. Hepatocyte nuclear factor 6: organization and chromosomal assignment of the rat gene and characterization of its promoter. Biochemical Journal 1998. 334: 565-569
Liu L, Nguyen H, Das U, Ogunsola S, Yu JK, Pejhan S, Rastegar M, Jiuyong Xie. Epigenetic control of adaptive or homeostatic splicing during interval-training activities. Nucleic Acid Research (NAR) 2024. gkae311 (1-14). Doi: https://doi.org/10.1093/nar/gkae311
Roberts C-H, Arezoumand K, Shahib AK, Davie JR, and Rastegar M. Epigenetics in rare neurological diseases. Frontiers in Cell & Developmental Biology 2024. In press
Lockman S, Genung M, Sheikholeslami K, Ali Sher A, Kroft D, Buist M, Olson CO, Toor B, and Rastegar M. Transcriptional inhibition of the Mecp2 promoter by MeCP2E1 and MeCP2E2 isoforms suggests negative auto-regulatory feedback that can be moderated by metformin. Journal of Molecular Neuroscience 2024. 74-14 (1-11). Doi: https://doi.org/10.1007/s12031-023-02177-0
Rastegar M. Editorial: New Insights into the Molecular Mechanisms of Autistic Spectrum Disorders. Frontiers in Molecular Neuroscience 2024. 17 (1-2). Doi: https://doi.org/10.3389/fnmol.2024.1363999
Nejati-Koshki K*, Roberts C*-H (*equal contribution), Babaei G, and Rastegar M. The Epigenetic Reader Methyl-CpG-Binding Protein 2 (MeCP2) Is an Emerging Oncogene in Cancer Biology. Cancers 2023. 15(10), 2683 (1-22); Doi: https://doi.org/10.3390/cancers15102683
Rastegar M, Davie JR. Editorial: MeCP2 is the Protector of Epigenome Integrity, Membrane-less Nuclear Architecture, and Stability of Chromatin Assembly. Epigenomics 2023. 15(20):1027-1031. Doi: https://doi.org/10.2217/epi-2023-0310
My Vuu Y, Shahib AK, and Rastegar M. The potential therapeutic application of simvastatin for brain complications and mechanisms of action. Pharmaceuticals 2023. 16, 914 (1-26). Doi: https://doi.org/10.3390/ph16070914
Sattarifard H, Safaei A, Khazeeva E, Rastegar M, and Davie JR. Mitogen- and stress-activated protein kinase (MSK1/2) regulated gene expression in normal and disease states. Biochemistry and Cell Biology 2023. Doi: 10.1139/bcb-2022-0371.
Vuu YM, Roberts C-T, Rastegar M. MeCP2 is an epigenetic factor that links DNA methylation with brain metabolism. International Journal of Molecular Sciences (IJMS) 2023. 24, 4, 4218 (1- 32). Doi: Doi.org/10.3390/ijms24044218
Cho WC, Pérez-Tur J, Giugno R, Pirooznia M, Boris-Lawrie K, Greenbaum D, Rastegar M, Henrique R, Xu P, Teixeira da Rocha JB, Rogina B. Editorial: 10 Years of Frontiers in Genetics: past discoveries, current challenges and future perspectives. Frontiers in Genetics 2023. Doi:10.3389/fgene.2023.1192071 (1-3)
Imani M, Mohajeri N, Rastegar M, and Nosratollah N. Synthesis and Characterization of N-rich Fluorescent Bio-dots as a Reporter in the Design of Dual-labeled FRET Probe for TaqMan PCR: a Feasibility Study. Biotechnology and Applied Biochemistry 2023. 70(2):645-658, Doi: 10.1002/bab.2387
Ruden DM, and Rastegar M. Editorial: Insights in Epigenomics and Epigenetics: 2022. Frontiers in Genetics 2023, 14 (1-2). Doi: https://doi.org/10.3389/fgene.2023.1205975
Buist M, El-Tobgy N, Shevkoplyas D, Genung M, Sher AA, Pejhan S, Rastegar M. Differential sensitivity of the protein translation initiation machinery and mTOR signaling to MECP2 gain- and loss-of-function involves MeCP2 isoform-specific homeostasis in the brain. Cells 2022. 11(9):1442 (1-32). Doi: https://doi.org/10.3390/cells11091442
Shevkoplyas D, Vuu YM, Davie JR, Rastegar M. The Chromatin structure at the MECP2 gene and in Silico prediction of potential coding and non-coding MECP2 splice variants. International Journal of Molecular Sciences (IJMS) 2022. 23, 24 (1-26). Doi.org/10.3390/ijms232415643
Nejati K, Rastegar M, Fathi F, Dadashpour M, Arabzadeh AA. Nanoparticle-based drug delivery systems to overcome gastric cancer drug resistance. Journal of Drug Delivery Science and Technology 2022, 70, 103231
Bin Akhtar G*, Buist M* (*equal contribution), Rastegar M. MeCP2 and transcriptional control of eukaryotic genes. European Journal of Cell Biology 2022 . 101, 3, 151237 (1-19). Doi: 10.1016/j.ejcb.2022.151237
Imani M, Mohajeri N, Rastegar M, Zarghami N. Synthesis and characterization of N‐rich fluorescent bio‐dots as a reporter in the design of dual‐labeled FRET probe for TaqMan PCR: A feasibility study. Biotechnology and Applied Biochemistry 2022. Doi.org/10.1002/bab.2387
Buist M, Fuss D, Rastegar M. Transcriptional regulation of MECP2E1-E2 Isoforms and BDNF by metformin and simvastatin through analyzing nascent RNA synthesis in a human brain cell line. Biomolecules 2021.11(8):1253 (1-19). Doi: 10.3390/biom11081253.
Rastegar M, Yasui DH. Editorial: Epigenetic mechanisms and their involvement in rare diseases. Frontiers in Genetics 2021. 12:755076. Doi: 10.3389/fgene.2021.755076
Imani N, Mohajeri N, Rastegar M, & Zarghami N. Recent advances in FRET-Based biosensors for biomedical applications. Analytical biochemistry 2021. 630, 114323 (1-14). Doi: 10.1016/j.ab.2021.114323
Pejhan S, & Rastegar M. Role of DNA-Methyl CpG-Binding protein MeCP2 in Rett Syndrome pathobiology and mechanism of disease. Biomolecules 2021. 11 (1) 75 (1-27). Doi: https://doi.org/10.3390/biom11010075
Amiri S, Davie JR, & Rastegar M. Chronic ethanol exposure alters DNA methylation in neural stem cells; Role of mouse strain and sex. Molecular Neurobiology 2020. 57, 2 (650-667), Doi.org/10.1007/s12035-019-01728-0
Pejhan S, Del Bigio MR, & Rastegar M. The MeCP2E1/E2-BDNF-miR132 homeostasis regulatory network is region-dependent in the human brain and is impaired in Rett Syndrome patients. Frontiers in Cell and Developmental Biology 2020. 7, 863 (1-14) Doi: 10.3389/fcell.2020.00763
Vriend J, & Rastegar M. Ubiquitin ligases and medulloblastoma: genetic markers of the four consensus subgroups identified through transcriptome datasets. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2020. 1866(10): 165839. Doi: 10.1016/j.bbadis.2020.165839
Pejhan S, Mok Siu V, Ang LC, Del Bigio MR, & Rastegar M. Differential brain region-specific expression of MeCP2 and BDNF in Rett Syndrome patients: A distinct grey-white matter variation. Neuropathology and Applied Neurobiology 2020. 46, 7 (735-750) Doi: 10.1111/nan.12619
Liyanage VRB, Olson CO, Zachariah RM, Davie JR, & Rastegar M. DNA methylation contributes to the differential expression levels of Mecp2 in male mice neurons and astrocytes. International Journal of Molecular Sciences 2019. 20(8), 1845: 1-15, Doi:10.3390/ijms20081845
Sheikholeslami K*, Ali Sher A*, Lockman S* (*equal contribution), Kroft D, Ghanjibakhsh M, Nejati-Koshki K, Shojaei S, Ghavami S, & Rastegar M. Simvastatin induces apoptosis in medulloblastoma brain tumor cells via mevalonate cascade prenylation substrates. Cancers 2019. 11(7), 994: 1-19, Doi: 10.3390/CANCERS11070994
Xu W, Liyanage VRB, MacAulay A, Levy RD, Curtis K, Olson CO, Zachariah RM, Amiri S, Buist M, Hicks GG, Davie JR, & Rastegar M. Genome-wide transcriptome landscape of embryonic brain-derived neural stem cells exposed to alcohol with strain-specific cross-examination in BL6 and CD1 mice. Scientific Reports 2019. 9:206: 1-17, Doi:10.1038/s41598-018-36059-y
Majidinia M, Reiter RJ, Shakouri SK, Mohebbi I, Rastegar M, Kaviani M, Darband SG, Jahanban-Esfahlan R, Nabavi SM, & Yousefi B. The multiple functions of melatonin in regenerative medicine. Ageing Research Reviews 2018. 45:33-52. Doi: 10.1016/j.arr.2018.04.003
Olson CO, Pejhan S, Kroft D, Sheikholeslami K, Fuss D, Buist M, Ali Sher A, Del Bigio MR, Sztainberg E, Siu VM, Ang LC, Sabourin-Felix M, Moss T, & Rastegar M. MECP2 mutation interrupts nucleolin-mTOR-P70S6K signaling in Rett Syndrome patients. Frontiers in Genetics 2018. 9, 635:1-17, Doi: 10.3389/fgene.2018.00635
Rastegar M. NeuroEpigenetics and neurodevelopmental disorders: From molecular mechanisms to cell fate commitments of the brain cells and human disease. Current Topics in Medicinal Chemistry 2017. 17,1. Doi: 10.2174/1568026616999160812144822
Amiri S, Haj-Mirzaiain A, Momeny M, Amini-Khoei H, Rahimi-Balaei M, Poursaman S, Rastegar M, Nikoui V, Mokhtari T, Ghazi-Khansari M, & Hosseini MJ. Streptozotocin induced oxidative stress, innate immune system responses and behavioral abnormalities in male mice. Neuroscience 2017. 340:373-383. Doi: 10.1016/j.neuroscience.2016.11.003
Amiri S, Haj-Mirzaian A, Amini-Khoei H, Razmi A, Shirzadian A, Rahimi-Balaei M, Olson CO, Mohsenzadeh A, Rastegar M, Zarrindast MR, & Ghazi-Khansari M. Protective effects of gabapentin against the seizure susceptibility and comorbid behavioral abnormalities in the early socially isolated mice. European Journal of Pharmacology 2017. 21; 797:106-114. Doi: 10.1016/j.ejphar.2017.01.024
Amini-Khoei H, Mohammadi-Asl A, Amiri S, Hosseini MJ, Momeny M, Hassanipour M, Rastegar M, Haj-Mirzaian A, Mirzaian AH, Sanjari moghaddam H, Mehr SE, & Dehpour AR. Oxytocin mitigated the depressive-like behaviors of maternal separation stress through modulating mitochondrial function and neuroinflammation. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2017. S0278-5846 (16)30244-5. Doi: 10.1016/j.pnpbp.2017.02.022
Liyanage VRB, Curtis K, Zachariah RM, Crudely A, & Rastegar M. Overview of the genetic basis and epigenetic mechanisms that contribute to FASD pathobiology. Current Topics in Medicinal Chemistry 2017. 17(7), 808-828, Doi: 10.2174/1568026616666160414124816
Amini-Khoei H, Amiri S, Mohammadi-Asl A, Alijanpour S, Poursaman S, Haj-Mirzaian A, Rastegar M, Mesdaghinia A, Banafshe HR, Sadeghi E, Samiei E, Mehr SE, & Dehpour AR. Experiencing neonatal maternal separation increased pain sensitivity in adult male mice: Involvement of oxytocinergic system. Neuropeptides 2017. 61:77-85. Doi: 10.1016/j.npep.2016.11.005
Pandian N, Iqbal MA, Yeung A, Thliveris JA, Rastegar M, Ghavami S, & Eftekharpour E. Perturbation of Redox Balance after Thioredoxin Reductase Deficiency Interrupts Autophagy-Lysosomal Degradation Pathway and Enhances Apoptotic Cell Death in Nutritionally Stressed SH-SY5Y Cells. Free Radical Biology & Medicine 2016. 16: 30440-3. Doi: 10.1016/j.freeradbiomed.2016.09.026
Amiri S, Haj-Mirzaian A, Amini-khoei H, Shirzadian A, Rahimi-Balaei M, Razmi A, Bergen H, Rastegar M, Kordjazy N, Haj-Mirzaian A, Ejtemai-Mehr S, & Dehpour R. Lithium attenuates the proconvulsant effect of adolescent social isolation stress via involvement of the nitrergic system. Epilepsy & Behavior 2016. Doi: http://dx.doi.org/10.1016/j.yebeh.2016.04.035
Amiri S*, Alijanpour S* (*equal contribution), Tirgar F, Haj-Mirzaian A, Amini-Khoei H, Rahimi-Balaei M, Rastegar M, Ghaderi M, Ghazi-Khansari M, & Zarrindast MR. NMDA receptors are involved in the antidepressant-like effects of capsaicin following amphetamine withdrawal in male mice. Neuroscience 2016. Doi: 10.1016/j.neuroscience.2016.05.003
Amiri S, Amini-Khoei H, Mohammadi-Asl A, Alijanpour S, Haj-Mirzaian A, Rahimi-Balaei M, Razmi A, Olson CO, Rastegar M, Mehdizadeh M, & Zarrindast MR. Involvement of D1 and D2 dopamine receptors in the antidepressant-like effects of selegiline in maternal separation model of mouse. Physiology and Behavior 2016. Doi: 10.1016/j.physbeh.2016.04.052
Haj-Mirzaian A, Amiri S, Amini-Khoei H, Rahimi-Balaei M, Kordjazy N, Olson CO, Rastegar M, Naserzadeh P, Marzban H, Dehpour AR, Hosseini MJ, & Ejtemaei Mehr SH. Attenuation of Oxidative and Nitrosative Stress in Cortical Area Contribute to Antidepressant-like Effects of Tropisetron in Male Mice Following Social Isolation Stress. Brain Research Bulletin 2016. Doi: 10.1016/j.brainresbull.2016.04.018
Liyanage VRB, Zachariah RM, Davie JR, & Rastegar M. Ethanol Deregulates Mecp2/MeCP2 in Differentiating Neural Stem Cells via Interplay between 5-Methylcytosine and 5-Hydroxymethylcytosine at the Mecp2 Regulatory Elements. Experimental Neurology 2015, 265: 102-117. Doi: 10.1016/j.expneurol.2015.01.006
Marzban H, Del Bigio MR, Alizadeh J, Ghavami S, Zachariah RM, & Rastegar M. Cellular Commitment in the Developing Cerebellum. Frontiers in Cellular Neuroscience 2015, 8 (450): 1-26. Doi: 10.3389/fncel.2014.00450
Olson CO*, Zachariah RM*, Ezeonwuka CD* (*equal contribution), Liyanage VRB, & Rastegar M. Brain Region-Specific Expression of MeCP2 Isoforms Correlates with DNA Methylation within Mecp2 Regulatory Elements. PLOS ONE 2014, 9(3): e90645. Doi: 10.1371/journal.pone.0090645
Liyanage VRB, & Rastegar M. Rett Syndrome and MeCP2. NeuroMolecular Medicine 2014. Doi: 10.1007/s12017-014-8295-9
Yasui DH, Gonzales ML, Aflatooni JO, Crary FK, Hu DJ, Gavino BJ, Golub MS, Vincent JB, Schanen NC, Olson CO, Rastegar M, & Lasalle JM. Mice with an Isoform-ablating Mecp2-exon 1 Mutation Recapitulate the Neurologic Deficits of Rett Syndrome. Human Molecular Genetics 2014. 1;23(9):2447-58. Doi: 10.1093/hmg/ddt640
Liyanage VRB, Jarmasz J, Murugeshan N, Del Bigio MR, Rastegar M, & Davie JR. DNA Modifications: Function and Applications in Normal and Disease States. Biology 2014. 22;3(4):670-723. Doi: 10.3390/biology3040670
Ezeonwuka CD, & Rastegar M. MeCP2-Related Diseases and Animal Models. Diseases 2014. 2 (1): 45-70
Liyanage VRB, Zachariah RM, & Rastegar M. Decitabine alters the Expression of Mecp2 Isoforms via Dynamic DNA Methylation at the Mecp2 Regulatory Elements in Neural Stem Cells. Molecular Autism 2013. 4:46. Doi: 10.1186/2040-2392-4-46
Barber BA*, Liyanage VRB* (*equal contribution), Zachariah RM, Olson C, Bailey M, & Rastegar M. Dynamic Expression of MEIS1 Homeoprotein in E14.5 Forebrain and Differentiated Forebrain-Derived Neural Stem Cells. Annals of Anatomy 2013. Doi: 10.1016/j.aanat.2013.04.00
Olynik B, & Rastegar M. The Genetic and Epigenetic Journey of Embryonic Stem Cells into Mature Neural Cells. Frontiers in Genetics 2012. 2012;3:81. 1-16.
Sandhu S, Wu X, Nabi Z, Rastegar M, Kung S, Mai S, & Ding H. Loss of HLTF Function Promotes Intestinal Carcinogenesis. Molecular Cancer 2012. 27; 11(1):18, 1-16.
Zachariah RM, & Rastegar M. Linking Epigenetics to Human Disease and Rett Syndrome, the Emerging Novel and Challenging Concepts in MeCP2 Research. Neural Plasticity 2012. 2012: 1-10.
Zachariah RM*, Olson C* (*equal contribution), Ezeowuka Ch, & Rastegar M. Novel MeCP2 Isoform-Specific Antibody Reveals the Endogenous MeCP2E1 Expression in Murine Brain, Primary Neurons and Astrocytes. PLOS ONE 2012. e49763. Doi: 10.1371; 7 (11): 1-10
Barber BA, & Rastegar M. Epigenetic Control of Hox Genes during Neurogenesis, Development and Disease. Annals of Anatomy 2010. 192(5): 261-74 [Artwork selected for cover]
Delcuve GP, Rastegar M, & Davie JR. Epigenetic Control. Journal of Cellular Physiology 2009, 219 (2): 243-50 [Artwork selected for cover]
Rastegar M, Hotta A, Pasceri P, Elliot S, Makarem M, Cheung A, Adachi M, Jones, FS, Clarke I, Dirks P, & Ellis J. Rett Syndrome Neural Stem Cell Gene Transfer with MECP2 Isoform-Specific Vectors. PLOS ONE 2009. 4(8): e6810. Doi: 10.1371, 1-15
Ellis J, Hotta A, & Rastegar M. Retrovirus Silencing by an Epigenetic TRIM. Cell 2007. 131(1): 13-14
Nolte C*, Rastegar M* (*equal contribution), Amores A, Bouchard M, Grote D, Maas R, Nagy Kovacs E, Postlethwait J, Rambaldi I, Rowan Sh, Zhang F, & Featherstone M. Stereospecificity and PAX6 function direct Hoxd4 neural enhancer activity along the antero-posterior axis. Developmental Biology 2006. 15-299(2): 582-93
Kobrossy L, Rastegar M, & Featherstone M. Interplay between chromatin and trans-acting factors regulating the Hoxd4 promoter during neural differentiation. The Journal of Biological Chemistry 2006. 281:25926-39
Huang H, Rastegar M, Bodner C, Goh SL, Rambaldi I, & Featherstone M. Meis C-termini harbor transcriptional activation domains that respond to cell signaling. The Journal of Biological Chemistry 2005. 280:10119-27
Rastegar M, Kobrossy L, Nagy Kovàcs E, Rambaldi I, & Featherstone M. Sequential histone modifications at Hoxd4 regulatory regions distinguish anterior from posterior embryonic compartments. Molecular and Cellular Biology 2004. 24: 8090-8103
Gordon J, Wu CH, Rastegar M, & Safa AR. 2-microglobulin induces caspase-dependent apoptosis in CCRF-HBS-2 human leukemia cell line independently of caspase-3, -8, and -9 pathways but through increased reactive oxygen species. International Journal of Cancer 2003. 103: 316-327
Wu CH, Gordon J, Rastegar M, Ogretmen B, & Safa AR. Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line is down-regulated in its doxorubicin-resistant variant. Oncogene 2002. 21: 5160-5174
Wu CH, Rastegar M, Gordon J, and Safa AR. 2-microglobulin induces apoptosis in HL-60 human leukemia cells and its multidrug resistantvariants overexpressing MRP1 but lacking Bax or overexpressing P- glycoprotein. Oncogene 2001. 25: 7006-7020
Rastegar M, Rousseau GG, & Lemaigre FP. CCAAT/Enhancer Binding Protein alpha (C/EBPa) is a mediator of growth hormone action in the liver and controls the expression of Hepatocyte Nuclear Factor-6 (HNF-6). Endocrinology 2000. 141: 1686-92
Rastegar M, Lemaigre FP, & Rousseau GG. HNF-6: Pièce maîtresse d’un réseau de facteurs de transcription hépatiques contrôlé par l’hormone de croissance. Médicine /Sciences 2000.16: 1106-1108
Lahuna O*, Rastegar M* (*equal contribution), Maiter D, Thissen JP, Lemaigre FP, & Rousseau GG. Involvement of STAT5 and HNF-4 in the transcriptional control of the Hnf6 gene by growth Hormone. Molecular Endocrinology 2000. 14: 285-94
Rastegar M, Lemaigre FP, & Rousseau GG. Control of gene expression by growth hormone in liver: Key role of a network of transcription factors. Molecular and Cellular Endocrinology 2000. 164: 1-4
Rastegar M, Szpirer C, Rousseau GG, & Lemaigre FP. Hepatocyte nuclear factor 6: organization and chromosomal assignment of the rat gene and characterization of its promoter. Biochemical Journal 1998. 334: 565-569
Book Chapters
Rastegar M. Development of the Cerebellum from Molecular Aspects to Diseases; Epigenetic Control and Cerebellar Neurodevelopmental Disorders. Springer International Publishing 2023, Springer International Publishing AG, Springer International Publishing 2023 (Updated re-print), Book Editor: H. Marzban. https://link.springer.com/chapter/10.1007/978-3-031-23104-9_13
Rastegar M. Development of the Cerebellum from Molecular Aspects to Diseases; Epigenetic and Cerebellar Neurodevelopmental Disorders. Chapter 10: Epigenetics and Cerebral Neurodevelopmental Disorders. Springer International Publishing 2017, Springer International Publishing 2017, 197-218
Delcuve GP, Khan DH, Liyanage VRB, Jahan S, Rastegar M, Kirshenbaum LA, and Davie JR. Epigenetics in Cardiac Disease; Epigenetics: Chromatin Organization and Function. Spinger's Cardiovascular Biological series. 2016, Springer Chams, 1-35
Liyanage VRB*, Zachariah RM* (*equal contribution), Delcuve GP, Davie JR, and Rastegar M. Advances in Genetics Research. Volume 13: Chromatin Structure and Epigenetics. Nova Science Publishers, Inc. 2015 (Updated, Cross-reference)
Liyanage VRB*, Zachariah RM* (*equal contribution), Delcuve GP, Davie JR, and Rastegar M. New Developments in Chromatin Research: An Epigenetic Perspective. Nova Science Publishers, Inc. 2012, 29-58
Rastegar M, Delcuve GP, and Davie JR. Human Stem Cell Technology and Biology: A Research Guide and Laboratory Manual. Perspectives in Human Stem Cell Technologies: Epigenetic Analysis of pluripotent cells. Wiley-Blackwell 2011, 273-288
Rastegar M. Development of the Cerebellum from Molecular Aspects to Diseases; Epigenetic Control and Cerebellar Neurodevelopmental Disorders. Springer International Publishing 2023, Springer International Publishing AG, Springer International Publishing 2023 (Updated re-print), Book Editor: H. Marzban. https://link.springer.com/chapter/10.1007/978-3-031-23104-9_13
Rastegar M. Development of the Cerebellum from Molecular Aspects to Diseases; Epigenetic and Cerebellar Neurodevelopmental Disorders. Chapter 10: Epigenetics and Cerebral Neurodevelopmental Disorders. Springer International Publishing 2017, Springer International Publishing 2017, 197-218
Delcuve GP, Khan DH, Liyanage VRB, Jahan S, Rastegar M, Kirshenbaum LA, and Davie JR. Epigenetics in Cardiac Disease; Epigenetics: Chromatin Organization and Function. Spinger's Cardiovascular Biological series. 2016, Springer Chams, 1-35
Liyanage VRB*, Zachariah RM* (*equal contribution), Delcuve GP, Davie JR, and Rastegar M. Advances in Genetics Research. Volume 13: Chromatin Structure and Epigenetics. Nova Science Publishers, Inc. 2015 (Updated, Cross-reference)
Liyanage VRB*, Zachariah RM* (*equal contribution), Delcuve GP, Davie JR, and Rastegar M. New Developments in Chromatin Research: An Epigenetic Perspective. Nova Science Publishers, Inc. 2012, 29-58
Rastegar M, Delcuve GP, and Davie JR. Human Stem Cell Technology and Biology: A Research Guide and Laboratory Manual. Perspectives in Human Stem Cell Technologies: Epigenetic Analysis of pluripotent cells. Wiley-Blackwell 2011, 273-288