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Peer-Reviewed Publications & Journal Articles
Vuu YM, Roberts C-T, Rastegar M. MeCP2 is an epigenetic factor that links DNA methylation with brain metabolism. International Journal of Molecular Sciences (IJMS) 2023. 24, 4, 4218 (1- 32). Doi.org/10.3390/ijms24044218
Buist M, El-Tobgy N, Shevkoplyas D, Genung M, Sher AA, Pejhan S, Rastegar M. Differential sensitivity of the protein translation initiation machinery and mTOR signaling to MECP2 gain- and loss-of-function involves MeCP2 isoform-specific homeostasis in the brain. Cells 2022. 11(9):1442 (1-32). Doi: https://doi.org/10.3390/cells11091442
Shevkoplyas D, Vuu YM, Davie JR, Rastegar M. The Chromatin structure at the MECP2 gene and in Silico prediction of potential coding and non-coding MECP2 splice variants. International Journal of Molecular Sciences (IJMS) 2022. 23, 24 (1-26). Doi.org/10.3390/ijms232415643
Nejati K, Rastegar M, Fathi F, Dadashpour M, Arabzadeh AA. Nanoparticle-based drug delivery systems to overcome gastric cancer drug resistance. Journal of Drug Delivery Science and Technology 2022, 70, 103231
Bin Akhtar G*, Buist M* (*equal contribution), Rastegar M. MeCP2 and transcriptional control of eukaryotic genes. European Journal of Cell Biology 2022 . 101, 3, 151237 (1-19). Doi: 10.1016/j.ejcb.2022.151237
Imani M, Mohajeri N, Rastegar M, Zarghami N. Synthesis and characterization of N‐rich fluorescent bio‐dots as a reporter in the design of dual‐labeled FRET probe for TaqMan PCR: A feasibility study. Biotechnology and Applied Biochemistry 2022. Doi.org/10.1002/bab.2387
Buist M, Fuss D, Rastegar M. Transcriptional regulation of MECP2E1-E2 Isoforms and BDNF by metformin and simvastatin through analyzing nascent RNA synthesis in a human brain cell line. Biomolecules 2021.11(8):1253 (1-19). Doi: 10.3390/biom11081253.
Rastegar M, Yasui DH. Editorial: Epigenetic mechanisms and their involvement in rare diseases. Frontiers in Genetics 2021. 12:755076. Doi: 10.3389/fgene.2021.755076
Imani N, Mohajeri N, Rastegar M, & Zarghami N. Recent advances in FRET-Based biosensors for biomedical applications. Analytical biochemistry 2021. 630, 114323 (1-14). Doi: 10.1016/j.ab.2021.114323
Pejhan S, & Rastegar M. Role of DNA-Methyl CpG-Binding protein MeCP2 in Rett Syndrome pathobiology and mechanism of disease. Biomolecules 2021. 11 (1) 75 (1-27). Doi: https://doi.org/10.3390/biom11010075
Amiri S, Davie JR, & Rastegar M. Chronic ethanol exposure alters DNA methylation in neural stem cells; Role of mouse strain and sex. Molecular Neurobiology 2020. 57, 2 (650-667), Doi.org/10.1007/s12035-019-01728-0
Pejhan S, Del Bigio MR, & Rastegar M. The MeCP2E1/E2-BDNF-miR132 homeostasis regulatory network is region-dependent in the human brain and is impaired in Rett Syndrome patients. Frontiers in Cell and Developmental Biology 2020. 7, 863 (1-14) Doi: 10.3389/fcell.2020.00763
Vriend J, & Rastegar M. Ubiquitin ligases and medulloblastoma: genetic markers of the four consensus subgroups identified through transcriptome datasets. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2020. 1866(10): 165839. Doi: 10.1016/j.bbadis.2020.165839
Pejhan S, Mok Siu V, Ang LC, Del Bigio MR, & Rastegar M. Differential brain region-specific expression of MeCP2 and BDNF in Rett Syndrome patients: A distinct grey-white matter variation. Neuropathology and Applied Neurobiology 2020. 46, 7 (735-750) Doi: 10.1111/nan.12619
Liyanage VRB, Olson CO, Zachariah RM, Davie JR, & Rastegar M. DNA methylation contributes to the differential expression levels of Mecp2 in male mice neurons and astrocytes. International Journal of Molecular Sciences 2019. 20(8), 1845: 1-15, Doi:10.3390/ijms20081845
Sheikholeslami K*, Ali Sher A*, Lockman S* (*equal contribution), Kroft D, Ghanjibakhsh M, Nejati-Koshki K, Shojaei S, Ghavami S, & Rastegar M. Simvastatin induces apoptosis in medulloblastoma brain tumor cells via mevalonate cascade prenylation substrates. Cancers 2019. 11(7), 994: 1-19, Doi: 10.3390/CANCERS11070994
Xu W, Liyanage VRB, MacAulay A, Levy RD, Curtis K, Olson CO, Zachariah RM, Amiri S, Buist M, Hicks GG, Davie JR, & Rastegar M. Genome-wide transcriptome landscape of embryonic brain-derived neural stem cells exposed to alcohol with strain-specific cross-examination in BL6 and CD1 mice. Scientific Reports 2019. 9:206: 1-17, Doi:10.1038/s41598-018-36059-y
Majidinia M, Reiter RJ, Shakouri SK, Mohebbi I, Rastegar M, Kaviani M, Darband SG, Jahanban-Esfahlan R, Nabavi SM, & Yousefi B. The multiple functions of melatonin in regenerative medicine. Ageing Research Reviews 2018. 45:33-52. Doi: 10.1016/j.arr.2018.04.003
Olson CO, Pejhan S, Kroft D, Sheikholeslami K, Fuss D, Buist M, Ali Sher A, Del Bigio MR, Sztainberg E, Siu VM, Ang LC, Sabourin-Felix M, Moss T, & Rastegar M. MECP2 mutation interrupts nucleolin-mTOR-P70S6K signaling in Rett Syndrome patients. Frontiers in Genetics 2018. 9, 635:1-17, Doi: 10.3389/fgene.2018.00635
Rastegar M. NeuroEpigenetics and neurodevelopmental disorders: From molecular mechanisms to cell fate commitments of the brain cells and human disease. Current Topics in Medicinal Chemistry 2017. 17,1. Doi: 10.2174/1568026616999160812144822
Amiri S, Haj-Mirzaiain A, Momeny M, Amini-Khoei H, Rahimi-Balaei M, Poursaman S, Rastegar M, Nikoui V, Mokhtari T, Ghazi-Khansari M, & Hosseini MJ. Streptozotocin induced oxidative stress, innate immune system responses and behavioral abnormalities in male mice. Neuroscience 2017. 340:373-383. Doi: 10.1016/j.neuroscience.2016.11.003
Amiri S, Haj-Mirzaian A, Amini-Khoei H, Razmi A, Shirzadian A, Rahimi-Balaei M, Olson CO, Mohsenzadeh A, Rastegar M, Zarrindast MR, & Ghazi-Khansari M. Protective effects of gabapentin against the seizure susceptibility and comorbid behavioral abnormalities in the early socially isolated mice. European Journal of Pharmacology 2017. 21; 797:106-114. Doi: 10.1016/j.ejphar.2017.01.024
Amini-Khoei H, Mohammadi-Asl A, Amiri S, Hosseini MJ, Momeny M, Hassanipour M, Rastegar M, Haj-Mirzaian A, Mirzaian AH, Sanjari moghaddam H, Mehr SE, & Dehpour AR. Oxytocin mitigated the depressive-like behaviors of maternal separation stress through modulating mitochondrial function and neuroinflammation. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2017. S0278-5846 (16)30244-5. Doi: 10.1016/j.pnpbp.2017.02.022
Liyanage VRB, Curtis K, Zachariah RM, Crudely A, & Rastegar M. Overview of the genetic basis and epigenetic mechanisms that contribute to FASD pathobiology. Current Topics in Medicinal Chemistry 2017. 17(7), 808-828, Doi: 10.2174/1568026616666160414124816
Amini-Khoei H, Amiri S, Mohammadi-Asl A, Alijanpour S, Poursaman S, Haj-Mirzaian A, Rastegar M, Mesdaghinia A, Banafshe HR, Sadeghi E, Samiei E, Mehr SE, & Dehpour AR. Experiencing neonatal maternal separation increased pain sensitivity in adult male mice: Involvement of oxytocinergic system. Neuropeptides 2017. 61:77-85. Doi: 10.1016/j.npep.2016.11.005
Pandian N, Iqbal MA, Yeung A, Thliveris JA, Rastegar M, Ghavami S, & Eftekharpour E. Perturbation of Redox Balance after Thioredoxin Reductase Deficiency Interrupts Autophagy-Lysosomal Degradation Pathway and Enhances Apoptotic Cell Death in Nutritionally Stressed SH-SY5Y Cells. Free Radical Biology & Medicine 2016. 16: 30440-3. Doi: 10.1016/j.freeradbiomed.2016.09.026
Amiri S, Haj-Mirzaian A, Amini-khoei H, Shirzadian A, Rahimi-Balaei M, Razmi A, Bergen H, Rastegar M, Kordjazy N, Haj-Mirzaian A, Ejtemai-Mehr S, & Dehpour R. Lithium attenuates the proconvulsant effect of adolescent social isolation stress via involvement of the nitrergic system. Epilepsy & Behavior 2016. Doi: http://dx.doi.org/10.1016/j.yebeh.2016.04.035
Amiri S*, Alijanpour S* (*equal contribution), Tirgar F, Haj-Mirzaian A, Amini-Khoei H, Rahimi-Balaei M, Rastegar M, Ghaderi M, Ghazi-Khansari M, & Zarrindast MR. NMDA receptors are involved in the antidepressant-like effects of capsaicin following amphetamine withdrawal in male mice. Neuroscience 2016. Doi: 10.1016/j.neuroscience.2016.05.003
Amiri S, Amini-Khoei H, Mohammadi-Asl A, Alijanpour S, Haj-Mirzaian A, Rahimi-Balaei M, Razmi A, Olson CO, Rastegar M, Mehdizadeh M, & Zarrindast MR. Involvement of D1 and D2 dopamine receptors in the antidepressant-like effects of selegiline in maternal separation model of mouse. Physiology and Behavior 2016. Doi: 10.1016/j.physbeh.2016.04.052
Haj-Mirzaian A, Amiri S, Amini-Khoei H, Rahimi-Balaei M, Kordjazy N, Olson CO, Rastegar M, Naserzadeh P, Marzban H, Dehpour AR, Hosseini MJ, & Ejtemaei Mehr SH. Attenuation of Oxidative and Nitrosative Stress in Cortical Area Contribute to Antidepressant-like Effects of Tropisetron in Male Mice Following Social Isolation Stress. Brain Research Bulletin 2016. Doi: 10.1016/j.brainresbull.2016.04.018
Liyanage VRB, Zachariah RM, Davie JR, & Rastegar M. Ethanol Deregulates Mecp2/MeCP2 in Differentiating Neural Stem Cells via Interplay between 5-Methylcytosine and 5-Hydroxymethylcytosine at the Mecp2 Regulatory Elements. Experimental Neurology 2015, 265: 102-117. Doi: 10.1016/j.expneurol.2015.01.006
Marzban H, Del Bigio MR, Alizadeh J, Ghavami S, Zachariah RM, & Rastegar M. Cellular Commitment in the Developing Cerebellum. Frontiers in Cellular Neuroscience 2015, 8 (450): 1-26. Doi: 10.3389/fncel.2014.00450
Olson CO*, Zachariah RM*, Ezeonwuka CD* (*equal contribution), Liyanage VRB, & Rastegar M. Brain Region-Specific Expression of MeCP2 Isoforms Correlates with DNA Methylation within Mecp2 Regulatory Elements. PLOS ONE 2014, 9(3): e90645. Doi: 10.1371/journal.pone.0090645
Liyanage VRB, & Rastegar M. Rett Syndrome and MeCP2. NeuroMolecular Medicine 2014. Doi: 10.1007/s12017-014-8295-9
Yasui DH, Gonzales ML, Aflatooni JO, Crary FK, Hu DJ, Gavino BJ, Golub MS, Vincent JB, Schanen NC, Olson CO, Rastegar M, & Lasalle JM. Mice with an Isoform-ablating Mecp2-exon 1 Mutation Recapitulate the Neurologic Deficits of Rett Syndrome. Human Molecular Genetics 2014. 1;23(9):2447-58. Doi: 10.1093/hmg/ddt640
Liyanage VRB, Jarmasz J, Murugeshan N, Del Bigio MR, Rastegar M, & Davie JR. DNA Modifications: Function and Applications in Normal and Disease States. Biology 2014. 22;3(4):670-723. Doi: 10.3390/biology3040670
Ezeonwuka CD, & Rastegar M. MeCP2-Related Diseases and Animal Models. Diseases 2014. 2 (1): 45-70
Liyanage VRB, Zachariah RM, & Rastegar M. Decitabine alters the Expression of Mecp2 Isoforms via Dynamic DNA Methylation at the Mecp2 Regulatory Elements in Neural Stem Cells. Molecular Autism 2013. 4:46. Doi: 10.1186/2040-2392-4-46
Barber BA*, Liyanage VRB* (*equal contribution), Zachariah RM, Olson C, Bailey M, & Rastegar M. Dynamic Expression of MEIS1 Homeoprotein in E14.5 Forebrain and Differentiated Forebrain-Derived Neural Stem Cells. Annals of Anatomy 2013. Doi: 10.1016/j.aanat.2013.04.00
Olynik B, & Rastegar M. The Genetic and Epigenetic Journey of Embryonic Stem Cells into Mature Neural Cells. Frontiers in Genetics 2012. 2012;3:81. 1-16.
Sandhu S, Wu X, Nabi Z, Rastegar M, Kung S, Mai S, & Ding H. Loss of HLTF Function Promotes Intestinal Carcinogenesis. Molecular Cancer 2012. 27; 11(1):18, 1-16.
Zachariah RM, & Rastegar M. Linking Epigenetics to Human Disease and Rett Syndrome, the Emerging Novel and Challenging Concepts in MeCP2 Research. Neural Plasticity 2012. 2012: 1-10.
Zachariah RM*, Olson C* (*equal contribution), Ezeowuka Ch, & Rastegar M. Novel MeCP2 Isoform-Specific Antibody Reveals the Endogenous MeCP2E1 Expression in Murine Brain, Primary Neurons and Astrocytes. PLOS ONE 2012. e49763. Doi: 10.1371; 7 (11): 1-10
Barber BA, & Rastegar M. Epigenetic Control of Hox Genes during Neurogenesis, Development and Disease. Annals of Anatomy 2010. 192(5): 261-74 [Artwork selected for cover]
Delcuve GP, Rastegar M, & Davie JR. Epigenetic Control. Journal of Cellular Physiology. 2009, 219 (2): 243-50 [Artwork selected for cover]
Rastegar M, Hotta A, Pasceri P, Elliot S, Makarem M, Cheung A, Adachi M, Jones, FS, Clarke I, Dirks P, & Ellis J. Rett Syndrome Neural Stem Cell Gene Transfer with MECP2 Isoform-Specific Vectors. PLOS ONE 2009. 4(8): e6810. Doi: 10.1371, 1-15
Ellis J, Hotta A, & Rastegar M. Retrovirus Silencing by an Epigenetic TRIM. Cell 2007. 131(1): 13-14
Nolte C*, Rastegar M* (*equal contribution), Amores A, Bouchard M, Grote D, Maas R, Nagy Kovacs E, Postlethwait J, Rambaldi I, Rowan Sh, Zhang F, & Featherstone M. Stereospecificity and PAX6 function direct Hoxd4 neural enhancer activity along the antero-posterior axis. Developmental Biology 2006. 15-299(2): 582-93
Kobrossy L, Rastegar M, & Featherstone M. Interplay between chromatin and trans-acting factors regulating the Hoxd4 promoter during neural differentiation. The Journal of Biological Chemistry 2006. 281:25926-39
Huang H, Rastegar M, Bodner C, Goh SL, Rambaldi I, & Featherstone M. Meis C-termini harbor transcriptional activation domains that respond to cell signaling. The Journal of Biological Chemistry 2005. 280:10119-27
Rastegar M, Kobrossy L, Nagy Kovàcs E, Rambaldi I, & Featherstone M. Sequential histone modifications at Hoxd4 regulatory regions distinguish anterior from posterior embryonic compartments. Molecular and Cellular Biology 2004. 24: 8090-8103
Gordon J, Wu CH, Rastegar M, & Safa AR. 2-microglobulin induces caspase-dependent apoptosis in CCRF-HBS-2 human leukemia cell line independently of caspase-3, -8, and -9 pathways but through increased reactive oxygen species. International Journal of Cancer 2003. 103: 316-327
Wu CH, Gordon J, Rastegar M, Ogretmen B, & Safa AR. Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line is down-regulated in its doxorubicin-resistant variant. Oncogene 2002. 21: 5160-5174
Wu CH, Rastegar M, Gordon J, and Safa AR. 2-microglobulin induces apoptosis in HL-60 human leukemia cells and its multidrug resistantvariants overexpressing MRP1 but lacking Bax or overexpressing P- glycoprotein. Oncogene 2001. 25: 7006-7020
Rastegar M, Rousseau GG, & Lemaigre FP. CCAAT/Enhancer Binding Protein alpha (C/EBPa) is a mediator of growth hormone action in the liver and controls the expression of Hepatocyte Nuclear Factor-6 (HNF-6). Endocrinology 2000. 141: 1686-92
Rastegar M, Lemaigre FP, & Rousseau GG. HNF-6: Pièce maîtresse d’un réseau de facteurs de transcription hépatiques contrôlé par l’hormone de croissance. Médicine /Sciences 2000.16: 1106-1108
Lahuna O*, Rastegar M* (*equal contribution), Maiter D, Thissen JP, Lemaigre FP, & Rousseau GG. Involvement of STAT5 and HNF-4 in the transcriptional control of the hnf6 gene by growth Hormone. Molecular Endocrinology 2000. 14: 285-94
Rastegar M, Lemaigre FP, & Rousseau GG. Control of gene expression by growth hormone in liver: Key role of a network of transcription factors. Molecular and Cellular Endocrinology 2000. 164: 1-4
Rastegar M, Szpirer C, Rousseau GG, & Lemaigre FP. Hepatocyte nuclear factor 6: organization and chromosomal assignment of the rat gene and characterization of its promoter. Biochemical Journal 1998. 334: 565-569
Buist M, El-Tobgy N, Shevkoplyas D, Genung M, Sher AA, Pejhan S, Rastegar M. Differential sensitivity of the protein translation initiation machinery and mTOR signaling to MECP2 gain- and loss-of-function involves MeCP2 isoform-specific homeostasis in the brain. Cells 2022. 11(9):1442 (1-32). Doi: https://doi.org/10.3390/cells11091442
Shevkoplyas D, Vuu YM, Davie JR, Rastegar M. The Chromatin structure at the MECP2 gene and in Silico prediction of potential coding and non-coding MECP2 splice variants. International Journal of Molecular Sciences (IJMS) 2022. 23, 24 (1-26). Doi.org/10.3390/ijms232415643
Nejati K, Rastegar M, Fathi F, Dadashpour M, Arabzadeh AA. Nanoparticle-based drug delivery systems to overcome gastric cancer drug resistance. Journal of Drug Delivery Science and Technology 2022, 70, 103231
Bin Akhtar G*, Buist M* (*equal contribution), Rastegar M. MeCP2 and transcriptional control of eukaryotic genes. European Journal of Cell Biology 2022 . 101, 3, 151237 (1-19). Doi: 10.1016/j.ejcb.2022.151237
Imani M, Mohajeri N, Rastegar M, Zarghami N. Synthesis and characterization of N‐rich fluorescent bio‐dots as a reporter in the design of dual‐labeled FRET probe for TaqMan PCR: A feasibility study. Biotechnology and Applied Biochemistry 2022. Doi.org/10.1002/bab.2387
Buist M, Fuss D, Rastegar M. Transcriptional regulation of MECP2E1-E2 Isoforms and BDNF by metformin and simvastatin through analyzing nascent RNA synthesis in a human brain cell line. Biomolecules 2021.11(8):1253 (1-19). Doi: 10.3390/biom11081253.
Rastegar M, Yasui DH. Editorial: Epigenetic mechanisms and their involvement in rare diseases. Frontiers in Genetics 2021. 12:755076. Doi: 10.3389/fgene.2021.755076
Imani N, Mohajeri N, Rastegar M, & Zarghami N. Recent advances in FRET-Based biosensors for biomedical applications. Analytical biochemistry 2021. 630, 114323 (1-14). Doi: 10.1016/j.ab.2021.114323
Pejhan S, & Rastegar M. Role of DNA-Methyl CpG-Binding protein MeCP2 in Rett Syndrome pathobiology and mechanism of disease. Biomolecules 2021. 11 (1) 75 (1-27). Doi: https://doi.org/10.3390/biom11010075
Amiri S, Davie JR, & Rastegar M. Chronic ethanol exposure alters DNA methylation in neural stem cells; Role of mouse strain and sex. Molecular Neurobiology 2020. 57, 2 (650-667), Doi.org/10.1007/s12035-019-01728-0
Pejhan S, Del Bigio MR, & Rastegar M. The MeCP2E1/E2-BDNF-miR132 homeostasis regulatory network is region-dependent in the human brain and is impaired in Rett Syndrome patients. Frontiers in Cell and Developmental Biology 2020. 7, 863 (1-14) Doi: 10.3389/fcell.2020.00763
Vriend J, & Rastegar M. Ubiquitin ligases and medulloblastoma: genetic markers of the four consensus subgroups identified through transcriptome datasets. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2020. 1866(10): 165839. Doi: 10.1016/j.bbadis.2020.165839
Pejhan S, Mok Siu V, Ang LC, Del Bigio MR, & Rastegar M. Differential brain region-specific expression of MeCP2 and BDNF in Rett Syndrome patients: A distinct grey-white matter variation. Neuropathology and Applied Neurobiology 2020. 46, 7 (735-750) Doi: 10.1111/nan.12619
Liyanage VRB, Olson CO, Zachariah RM, Davie JR, & Rastegar M. DNA methylation contributes to the differential expression levels of Mecp2 in male mice neurons and astrocytes. International Journal of Molecular Sciences 2019. 20(8), 1845: 1-15, Doi:10.3390/ijms20081845
Sheikholeslami K*, Ali Sher A*, Lockman S* (*equal contribution), Kroft D, Ghanjibakhsh M, Nejati-Koshki K, Shojaei S, Ghavami S, & Rastegar M. Simvastatin induces apoptosis in medulloblastoma brain tumor cells via mevalonate cascade prenylation substrates. Cancers 2019. 11(7), 994: 1-19, Doi: 10.3390/CANCERS11070994
Xu W, Liyanage VRB, MacAulay A, Levy RD, Curtis K, Olson CO, Zachariah RM, Amiri S, Buist M, Hicks GG, Davie JR, & Rastegar M. Genome-wide transcriptome landscape of embryonic brain-derived neural stem cells exposed to alcohol with strain-specific cross-examination in BL6 and CD1 mice. Scientific Reports 2019. 9:206: 1-17, Doi:10.1038/s41598-018-36059-y
Majidinia M, Reiter RJ, Shakouri SK, Mohebbi I, Rastegar M, Kaviani M, Darband SG, Jahanban-Esfahlan R, Nabavi SM, & Yousefi B. The multiple functions of melatonin in regenerative medicine. Ageing Research Reviews 2018. 45:33-52. Doi: 10.1016/j.arr.2018.04.003
Olson CO, Pejhan S, Kroft D, Sheikholeslami K, Fuss D, Buist M, Ali Sher A, Del Bigio MR, Sztainberg E, Siu VM, Ang LC, Sabourin-Felix M, Moss T, & Rastegar M. MECP2 mutation interrupts nucleolin-mTOR-P70S6K signaling in Rett Syndrome patients. Frontiers in Genetics 2018. 9, 635:1-17, Doi: 10.3389/fgene.2018.00635
Rastegar M. NeuroEpigenetics and neurodevelopmental disorders: From molecular mechanisms to cell fate commitments of the brain cells and human disease. Current Topics in Medicinal Chemistry 2017. 17,1. Doi: 10.2174/1568026616999160812144822
Amiri S, Haj-Mirzaiain A, Momeny M, Amini-Khoei H, Rahimi-Balaei M, Poursaman S, Rastegar M, Nikoui V, Mokhtari T, Ghazi-Khansari M, & Hosseini MJ. Streptozotocin induced oxidative stress, innate immune system responses and behavioral abnormalities in male mice. Neuroscience 2017. 340:373-383. Doi: 10.1016/j.neuroscience.2016.11.003
Amiri S, Haj-Mirzaian A, Amini-Khoei H, Razmi A, Shirzadian A, Rahimi-Balaei M, Olson CO, Mohsenzadeh A, Rastegar M, Zarrindast MR, & Ghazi-Khansari M. Protective effects of gabapentin against the seizure susceptibility and comorbid behavioral abnormalities in the early socially isolated mice. European Journal of Pharmacology 2017. 21; 797:106-114. Doi: 10.1016/j.ejphar.2017.01.024
Amini-Khoei H, Mohammadi-Asl A, Amiri S, Hosseini MJ, Momeny M, Hassanipour M, Rastegar M, Haj-Mirzaian A, Mirzaian AH, Sanjari moghaddam H, Mehr SE, & Dehpour AR. Oxytocin mitigated the depressive-like behaviors of maternal separation stress through modulating mitochondrial function and neuroinflammation. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2017. S0278-5846 (16)30244-5. Doi: 10.1016/j.pnpbp.2017.02.022
Liyanage VRB, Curtis K, Zachariah RM, Crudely A, & Rastegar M. Overview of the genetic basis and epigenetic mechanisms that contribute to FASD pathobiology. Current Topics in Medicinal Chemistry 2017. 17(7), 808-828, Doi: 10.2174/1568026616666160414124816
Amini-Khoei H, Amiri S, Mohammadi-Asl A, Alijanpour S, Poursaman S, Haj-Mirzaian A, Rastegar M, Mesdaghinia A, Banafshe HR, Sadeghi E, Samiei E, Mehr SE, & Dehpour AR. Experiencing neonatal maternal separation increased pain sensitivity in adult male mice: Involvement of oxytocinergic system. Neuropeptides 2017. 61:77-85. Doi: 10.1016/j.npep.2016.11.005
Pandian N, Iqbal MA, Yeung A, Thliveris JA, Rastegar M, Ghavami S, & Eftekharpour E. Perturbation of Redox Balance after Thioredoxin Reductase Deficiency Interrupts Autophagy-Lysosomal Degradation Pathway and Enhances Apoptotic Cell Death in Nutritionally Stressed SH-SY5Y Cells. Free Radical Biology & Medicine 2016. 16: 30440-3. Doi: 10.1016/j.freeradbiomed.2016.09.026
Amiri S, Haj-Mirzaian A, Amini-khoei H, Shirzadian A, Rahimi-Balaei M, Razmi A, Bergen H, Rastegar M, Kordjazy N, Haj-Mirzaian A, Ejtemai-Mehr S, & Dehpour R. Lithium attenuates the proconvulsant effect of adolescent social isolation stress via involvement of the nitrergic system. Epilepsy & Behavior 2016. Doi: http://dx.doi.org/10.1016/j.yebeh.2016.04.035
Amiri S*, Alijanpour S* (*equal contribution), Tirgar F, Haj-Mirzaian A, Amini-Khoei H, Rahimi-Balaei M, Rastegar M, Ghaderi M, Ghazi-Khansari M, & Zarrindast MR. NMDA receptors are involved in the antidepressant-like effects of capsaicin following amphetamine withdrawal in male mice. Neuroscience 2016. Doi: 10.1016/j.neuroscience.2016.05.003
Amiri S, Amini-Khoei H, Mohammadi-Asl A, Alijanpour S, Haj-Mirzaian A, Rahimi-Balaei M, Razmi A, Olson CO, Rastegar M, Mehdizadeh M, & Zarrindast MR. Involvement of D1 and D2 dopamine receptors in the antidepressant-like effects of selegiline in maternal separation model of mouse. Physiology and Behavior 2016. Doi: 10.1016/j.physbeh.2016.04.052
Haj-Mirzaian A, Amiri S, Amini-Khoei H, Rahimi-Balaei M, Kordjazy N, Olson CO, Rastegar M, Naserzadeh P, Marzban H, Dehpour AR, Hosseini MJ, & Ejtemaei Mehr SH. Attenuation of Oxidative and Nitrosative Stress in Cortical Area Contribute to Antidepressant-like Effects of Tropisetron in Male Mice Following Social Isolation Stress. Brain Research Bulletin 2016. Doi: 10.1016/j.brainresbull.2016.04.018
Liyanage VRB, Zachariah RM, Davie JR, & Rastegar M. Ethanol Deregulates Mecp2/MeCP2 in Differentiating Neural Stem Cells via Interplay between 5-Methylcytosine and 5-Hydroxymethylcytosine at the Mecp2 Regulatory Elements. Experimental Neurology 2015, 265: 102-117. Doi: 10.1016/j.expneurol.2015.01.006
Marzban H, Del Bigio MR, Alizadeh J, Ghavami S, Zachariah RM, & Rastegar M. Cellular Commitment in the Developing Cerebellum. Frontiers in Cellular Neuroscience 2015, 8 (450): 1-26. Doi: 10.3389/fncel.2014.00450
Olson CO*, Zachariah RM*, Ezeonwuka CD* (*equal contribution), Liyanage VRB, & Rastegar M. Brain Region-Specific Expression of MeCP2 Isoforms Correlates with DNA Methylation within Mecp2 Regulatory Elements. PLOS ONE 2014, 9(3): e90645. Doi: 10.1371/journal.pone.0090645
Liyanage VRB, & Rastegar M. Rett Syndrome and MeCP2. NeuroMolecular Medicine 2014. Doi: 10.1007/s12017-014-8295-9
Yasui DH, Gonzales ML, Aflatooni JO, Crary FK, Hu DJ, Gavino BJ, Golub MS, Vincent JB, Schanen NC, Olson CO, Rastegar M, & Lasalle JM. Mice with an Isoform-ablating Mecp2-exon 1 Mutation Recapitulate the Neurologic Deficits of Rett Syndrome. Human Molecular Genetics 2014. 1;23(9):2447-58. Doi: 10.1093/hmg/ddt640
Liyanage VRB, Jarmasz J, Murugeshan N, Del Bigio MR, Rastegar M, & Davie JR. DNA Modifications: Function and Applications in Normal and Disease States. Biology 2014. 22;3(4):670-723. Doi: 10.3390/biology3040670
Ezeonwuka CD, & Rastegar M. MeCP2-Related Diseases and Animal Models. Diseases 2014. 2 (1): 45-70
Liyanage VRB, Zachariah RM, & Rastegar M. Decitabine alters the Expression of Mecp2 Isoforms via Dynamic DNA Methylation at the Mecp2 Regulatory Elements in Neural Stem Cells. Molecular Autism 2013. 4:46. Doi: 10.1186/2040-2392-4-46
Barber BA*, Liyanage VRB* (*equal contribution), Zachariah RM, Olson C, Bailey M, & Rastegar M. Dynamic Expression of MEIS1 Homeoprotein in E14.5 Forebrain and Differentiated Forebrain-Derived Neural Stem Cells. Annals of Anatomy 2013. Doi: 10.1016/j.aanat.2013.04.00
Olynik B, & Rastegar M. The Genetic and Epigenetic Journey of Embryonic Stem Cells into Mature Neural Cells. Frontiers in Genetics 2012. 2012;3:81. 1-16.
Sandhu S, Wu X, Nabi Z, Rastegar M, Kung S, Mai S, & Ding H. Loss of HLTF Function Promotes Intestinal Carcinogenesis. Molecular Cancer 2012. 27; 11(1):18, 1-16.
Zachariah RM, & Rastegar M. Linking Epigenetics to Human Disease and Rett Syndrome, the Emerging Novel and Challenging Concepts in MeCP2 Research. Neural Plasticity 2012. 2012: 1-10.
Zachariah RM*, Olson C* (*equal contribution), Ezeowuka Ch, & Rastegar M. Novel MeCP2 Isoform-Specific Antibody Reveals the Endogenous MeCP2E1 Expression in Murine Brain, Primary Neurons and Astrocytes. PLOS ONE 2012. e49763. Doi: 10.1371; 7 (11): 1-10
Barber BA, & Rastegar M. Epigenetic Control of Hox Genes during Neurogenesis, Development and Disease. Annals of Anatomy 2010. 192(5): 261-74 [Artwork selected for cover]
Delcuve GP, Rastegar M, & Davie JR. Epigenetic Control. Journal of Cellular Physiology. 2009, 219 (2): 243-50 [Artwork selected for cover]
Rastegar M, Hotta A, Pasceri P, Elliot S, Makarem M, Cheung A, Adachi M, Jones, FS, Clarke I, Dirks P, & Ellis J. Rett Syndrome Neural Stem Cell Gene Transfer with MECP2 Isoform-Specific Vectors. PLOS ONE 2009. 4(8): e6810. Doi: 10.1371, 1-15
Ellis J, Hotta A, & Rastegar M. Retrovirus Silencing by an Epigenetic TRIM. Cell 2007. 131(1): 13-14
Nolte C*, Rastegar M* (*equal contribution), Amores A, Bouchard M, Grote D, Maas R, Nagy Kovacs E, Postlethwait J, Rambaldi I, Rowan Sh, Zhang F, & Featherstone M. Stereospecificity and PAX6 function direct Hoxd4 neural enhancer activity along the antero-posterior axis. Developmental Biology 2006. 15-299(2): 582-93
Kobrossy L, Rastegar M, & Featherstone M. Interplay between chromatin and trans-acting factors regulating the Hoxd4 promoter during neural differentiation. The Journal of Biological Chemistry 2006. 281:25926-39
Huang H, Rastegar M, Bodner C, Goh SL, Rambaldi I, & Featherstone M. Meis C-termini harbor transcriptional activation domains that respond to cell signaling. The Journal of Biological Chemistry 2005. 280:10119-27
Rastegar M, Kobrossy L, Nagy Kovàcs E, Rambaldi I, & Featherstone M. Sequential histone modifications at Hoxd4 regulatory regions distinguish anterior from posterior embryonic compartments. Molecular and Cellular Biology 2004. 24: 8090-8103
Gordon J, Wu CH, Rastegar M, & Safa AR. 2-microglobulin induces caspase-dependent apoptosis in CCRF-HBS-2 human leukemia cell line independently of caspase-3, -8, and -9 pathways but through increased reactive oxygen species. International Journal of Cancer 2003. 103: 316-327
Wu CH, Gordon J, Rastegar M, Ogretmen B, & Safa AR. Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line is down-regulated in its doxorubicin-resistant variant. Oncogene 2002. 21: 5160-5174
Wu CH, Rastegar M, Gordon J, and Safa AR. 2-microglobulin induces apoptosis in HL-60 human leukemia cells and its multidrug resistantvariants overexpressing MRP1 but lacking Bax or overexpressing P- glycoprotein. Oncogene 2001. 25: 7006-7020
Rastegar M, Rousseau GG, & Lemaigre FP. CCAAT/Enhancer Binding Protein alpha (C/EBPa) is a mediator of growth hormone action in the liver and controls the expression of Hepatocyte Nuclear Factor-6 (HNF-6). Endocrinology 2000. 141: 1686-92
Rastegar M, Lemaigre FP, & Rousseau GG. HNF-6: Pièce maîtresse d’un réseau de facteurs de transcription hépatiques contrôlé par l’hormone de croissance. Médicine /Sciences 2000.16: 1106-1108
Lahuna O*, Rastegar M* (*equal contribution), Maiter D, Thissen JP, Lemaigre FP, & Rousseau GG. Involvement of STAT5 and HNF-4 in the transcriptional control of the hnf6 gene by growth Hormone. Molecular Endocrinology 2000. 14: 285-94
Rastegar M, Lemaigre FP, & Rousseau GG. Control of gene expression by growth hormone in liver: Key role of a network of transcription factors. Molecular and Cellular Endocrinology 2000. 164: 1-4
Rastegar M, Szpirer C, Rousseau GG, & Lemaigre FP. Hepatocyte nuclear factor 6: organization and chromosomal assignment of the rat gene and characterization of its promoter. Biochemical Journal 1998. 334: 565-569
Book Chapters
Rastegar M. Development of the Cerebellum from Molecular Aspects to Diseases; Epigenetic and Cerebellar Neurodevelopmental Disorders. Chapter 10: Epigenetics and Cerebral Neurodevelopmental Disorders. Springer International Publishing 2017, Springer International Publishing 2017, 197-218
Delcuve GP, Khan DH, Liyanage VRB, Jahan S, Rastegar M, Kirshenbaum LA, and Davie JR. Epigenetics in Cardiac Disease; Epigenetics: Chromatin Organization and Function. Spinger's Cardiovascular Biological series. 2016, Springer Chams, 1-35
Liyanage VRB*, Zachariah RM* (*equal contribution), Delcuve GP, Davie JR, and Rastegar M. Advances in Genetics Research. Volume 13: Chromatin Structure and Epigenetics. Nova Science Publishers, Inc. 2015 (Cross-reference)
Liyanage VRB*, Zachariah RM* (*equal contribution), Delcuve GP, Davie JR, and Rastegar M. New Developments in Chromatin Research: An Epigenetic Perspective. Nova Science Publishers, Inc. 2012, 29-58
Rastegar M, Delcuve GP, and Davie JR. Human Stem Cell Technology and Biology: A Research Guide and Laboratory Manual. Perspectives in Human Stem Cell Technologies: Epigenetic Analysis of pluripotent cells. Wiley-Blackwell 2011, 273-288
Rastegar M. Development of the Cerebellum from Molecular Aspects to Diseases; Epigenetic and Cerebellar Neurodevelopmental Disorders. Chapter 10: Epigenetics and Cerebral Neurodevelopmental Disorders. Springer International Publishing 2017, Springer International Publishing 2017, 197-218
Delcuve GP, Khan DH, Liyanage VRB, Jahan S, Rastegar M, Kirshenbaum LA, and Davie JR. Epigenetics in Cardiac Disease; Epigenetics: Chromatin Organization and Function. Spinger's Cardiovascular Biological series. 2016, Springer Chams, 1-35
Liyanage VRB*, Zachariah RM* (*equal contribution), Delcuve GP, Davie JR, and Rastegar M. Advances in Genetics Research. Volume 13: Chromatin Structure and Epigenetics. Nova Science Publishers, Inc. 2015 (Cross-reference)
Liyanage VRB*, Zachariah RM* (*equal contribution), Delcuve GP, Davie JR, and Rastegar M. New Developments in Chromatin Research: An Epigenetic Perspective. Nova Science Publishers, Inc. 2012, 29-58
Rastegar M, Delcuve GP, and Davie JR. Human Stem Cell Technology and Biology: A Research Guide and Laboratory Manual. Perspectives in Human Stem Cell Technologies: Epigenetic Analysis of pluripotent cells. Wiley-Blackwell 2011, 273-288